As with most arachnids, the male of the species is smaller than the female though Desert Tarantulas in general are noted for their large size compared to other spiders. Leg spans can reach up to 4 inches in diameter on the females, making it possible for them to cover the whole hand of a grown man. Their bodies are also covered in an abundance of hair. This bristly hair is the hallmark of identifying Tarantulas, in general. Males are generally all dark in color, whereas females tend to have light brown (blonde)hairs on their carapace ('shoulders') and legs.
This spider will work hard at avoiding contact with people, and it will strike if disturbed or threatened. It should be noted that Desert Tarantula bites are considered to be poisonous, though not deadly. Seeking medical assistance is advisable if bitten. In general, Desert Tarantula venom is reported to only be as dangerous as bee venom, but deadly allergic reaction may result in sensitive individuals as every body is different.
Given their size, Desert Tarantulas are able to take down and consume small reptiles in addition to insects. Spiderlings hatch from eggs laid by the female and young male spiders eventually develop the large hairy pedipalps at the front of the face. Females can have great longevity and some have been known to have life spans of up to 20 years.