Orange-Kneed Tarantulas became popular 'pets' and were taken from the wild and sold in stores. Their trade has now become illegal and they are protected as an endangered species by being placed on the CITES list.
Males are generally smaller and thinner than females, though their legs are longer. They are territorial and aggressive with other intruding males. Females are larger and live longer by an average of 10-20 years longer. Males generally live about 10 years, when they become sexually mature, and then die.
North American tarantula venom is not lethal, but bites can be as painful as a bee sting. Also, the bristles on their abdomen break off easily and can penetrate skin, causing irritation and redness to prey (mice) or people trying to handle them. This is a 'look, but don't touch' species.
Nocturnal in nature, they are most active at night and are hunters, not spinners. They may use their silk to line their daytime hideouts, but not to catch prey.